Cayman E-64d; Purity- Greater Than Or Equal To 98%; Size- 1 Mg

Octahydrocurcumin is an active metabolite of curcumin (Item Nos. | ) that has diverse biological activities.^,,, It scavenges DPPH radicals in a cell-free assay (IC₅₀ = 12.3 µM). Octahydrocurcumin (6.25 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels, production of nitric oxide (NO), and nuclear translocation of NF-ᴋB in RAW 264.7 cells. It is active against the bacteria B. subtilis, K. pneumoniae, E. coli, E. aerogenes, P. aeruginosa, and S. aureus, as well as C. albicans, in disc assays. Octahydrocurcumin (5, 10, and 20 mg/kg) increases survival, reduces tumor weight, and induces tumor cell apoptosis in an H22 murine hepatocellular carcinoma model.

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