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Cayman Zm 447439; Purity- Greater Than Or Equal To 98%; Size- 50
NETA PART: | CAYM-13601-50 |
MFG.PART: | 13601-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin.1 ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively).2 It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 µM).3 ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis.3,4 Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-13601-50 |
---|---|
Supplier Part Number | 13601-50 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13601m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 331771-20-1 |