Cayman Icariin; Purity- Greater Than Or Equal To 97%; Size- 1 G;

Icariin is a prenylated flavonoid that has been found in E. pubescens and has diverse biological activities.^,,, It induces the differentiation of ES-D3 embryonic stem cells into cardiomyocytes when used at concentrations of 10 and 100 µM. Icariin (10 µM) increases the mRNA expression of RUNX family transcription factor 2 (Runx2), osteocalcin (Bgp), and bone sialoprotein (Bsp), gene markers of osteogenesis, in MC3T3-E1 preosteoblast cells. It reduces IL-6 and TNF-α protein levels induced by LPS in HeLa and RAW 264.7 cells when used at a concentration of 30 µM. Icariin (0.1 µM) prevents decreases in the levels of the neural integrity markers neurofilament heavy polypeptide (NF-H) and microtubule-associated protein 2 (MAP-2) induced by amyloid-β (1-42) (Aβ42) in primary E18 rat cortical neurons, and it improves spatial memory impairments in the Morris water maze in a 5XFAD transgenic mouse model of Alzheimers disease when administered at a dose of 34 mg/kg for eight days.

WARNING This product is not for human or veterinary use.