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Cayman Adapalene; Purity- Greater Than Or Equal To 98%; Size- 1 G
NETA PART: | CAYM-13655-1 |
MFG.PART: | 13655-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 μM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis.
WARNING This product is not for human or veterinary use.
Technical Information
- 3-
Aminopyridine- 2- Carboxyaldehyde Thiosemicarbazone - NSC 663249
- Triapine
- DMF: 25 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 20 mg/ml
Shipping & Storage Information
SKU | CAYM-13655-1 |
---|---|
Supplier Part Number | 13655-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13655m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 106685-40-9 |