We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Cay10408; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
Cayman Cay10408; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$668.00
Your Price
$668.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13747-5 |
| MFG.PART: | 13747-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation., At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(hexahydro-4-methyl-
CAS Number
1138549-36-6
Molecular Formula
C27H27N7O2S
Formula Weight
513.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 1 mg/ml
- Ethanol: 0.1 mg/ml
λmax
242, 292, 299, 339 nm
SMILES
CC1=NC=C(CNC(C2=C3N(C(C=CC=C4)=C4S3)C5=C(C=CC(N6CCCN(C)CC6)=N5)C2=O)=O)N=C1
InChi Code
InChI=1S/C27H27N7O2S/c1-17-14-29-18(15-28-17)16-30-26(36)23-24(35)19-8-9-22(33-11-5-10-32(2)12-13-33)31-25(19)34-20-6-3-4-7-21(20)37-27(23)34/h3-4,6-9,14-15H,5,10-13,16H2,1-2H3,(H,30,36)
InChi Key
XGPBJCHFROADCK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13747-5 |
|---|---|
| Supplier Part Number | 13747-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13747m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 212310-16-2 |