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Cayman 11 Betamisoprostol; Purity- Greater Than Or Equal To 98%
Cayman 11 Beta -Misoprostol; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$332.00
Your Price
$332.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-13825-1 |
MFG.PART: | 13825-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04928473 (SNX-2112; Item No. ), which binds both Hsp90α and Hsp90β with an IC50 value of 30 nM., The prodrug, PF-04929113, is rapidly absorbed and converted into the active inhibitor after oral administration. The active inhibitor causes degradation of Hsp90 client proteins, including HER2, and reduces phosphorylation of downstream kinases, including Akt and ERK1/2, leading to apoptosis in cancer cells., Oral administration of the prodrug, PF-04929113, reduces tumor growth and prolongs survival in mouse models of multiple myeloma and prostate cancer.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
glycine, trans- 4- [[2- (aminocarbonyl)- 5- [4,5,6,7- tetrahydro- 6,6- dimethyl- 4- oxo- 3- (trifluoromethyl)- 1H- indazol- 1- yl]phenyl]amino]cyclohexyl ester
CAS Number
908115-27-5
Synonyms
- SNX-5422
Molecular Formula
C25H30F3N5O4
Formula Weight
521.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 0.25 mg/ml
- DMSO: 1 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
250, 359 nm
SMILES
O=C(CN)O[C@@H](CC1)CC[C@H]1NC2=CC(N3N=C(C(F)(F)F)C4=C3CC(C)(C)CC4=O)=CC=C2C(N)=O
InChi Code
InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26,27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5,8-9,13,15,31H,3-4,6-7,10-12,29H2,1-2H3,(H2,30,36)/t13-,15-
InChi Key
AVDSOVJPJZVBTC-CTYIDZIISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-13825-1 |
---|---|
Supplier Part Number | 13825-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13825m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 58717-36-5 |