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Cayman Pd 150606; Purity- Greater Than Or Equal To 98%; Size- 5 M
Cayman Pd 150606; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$85.00
Your Price
$85.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-13859-5 |
MFG.PART: | 13859-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors). It is selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 μM) or affect HIV replication in MT-2 cells (EC50 = >30 μM). Formulations containing cobicistat have been used to slow the metabolism of concomitantly administered protease inhibitors in the treatment of HIV.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3R,6R,9S)- 12-methyl-13- [2-(1-methyl ethyl)-4- thiazolyl]-9- [2-(4- morpholinyl) ethyl]-8,11- dioxo-3,6-bis (phenyl methyl)- 2,7,10,12- tetraazatride canoic acid, 5-thiazolyl methyl ester
CAS Number
1004316-88-4
Synonyms
- GS-9350
Molecular Formula
C40H53N7O5S2
Formula Weight
776.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 10 mg/ml
λmax
203, 242 nm
SMILES
O=C([C@H](CCN1CCOCC1)NC(N(C)CC2=CSC(C(C)C)=N2)=O)N[C@H](CC[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4)CC5=CC=CC=C5
InChi Code
InChI=1S/C40H53N7O5S2/c1-29(2)38-43-34(27-53-38)25-46(3)39(49)45-36(16-17-47-18-20-51-21-19-47)37(48)42-32(22-30-10-6-4-7-11-30)14-15-33(23-31-12-8-5-9-13-31)44-40(50)52-26-35-24-41-28-54-35/h4-13,24,27-29,32-33,36H,14-23,25-26H2,1-3H3,(H,42,48)(H,44,50)(H,45,49)/t32-,33-,36+/m1/s1
InChi Key
ZCIGNRJZKPOIKD-CQXVEOKZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-13859-5 |
---|---|
Supplier Part Number | 13859-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13859m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CH |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 179528-45-1 |