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Cayman Iwp-2-V2; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
Cayman Iwp-2-V2; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$176.00
Your Price
$176.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13952-5 |
| MFG.PART: | 13952-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins., This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras. It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM). FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine, trifluoroacetate salt
Synonyms
- Farnesyltransferase Inhibitor II
- FTI-II
Molecular Formula
C15H21N3O4S2 • XCF3COOH
Formula Weight
371.5
Purity
≥80%
Formulation
A crystalline solid
Solubility
- Water: 25 mg/ml
λmax
211, 268 nm
SMILES
O=C(N[C@H](C(O)=O)CCSC)C1=CC=C(NC([C@@H](N)CS)=O)C=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C15H21N3O4S2.C2HF3O2/c1-24-7-6-12(15(21)22)18-13(19)9-2-4-10(5-3-9)17-14(20)11(16)8-23;3-2(4,5)1(6)7/h2-5,11-12,23H,6-8,16H2,1H3,(H,17,20)(H,18,19)(H,21,22);(H,6,7)/t11-,12-;/m0./s1
InChi Key
JZRHODCELOILNW-FXMYHANSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13952-5 |
|---|---|
| Supplier Part Number | 13952-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13952m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 877618-79-6 |