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Cayman Jwh 116; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
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NETA PART: | CAYM-13977-1 |
MFG.PART: | 13977-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with diverse biological activities. It belongs to the calcitonin family of peptides, which also includes amylin (Item No. ), calcitonin (Item Nos. | ), and adrenomedullin. α-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.1 nM) over a complex of CLCR and RAMP2 (IC50 = 1,300 nM). It also binds selectively to complexes of human calcitonin receptor 2 (CTR2) and RAMP1 (IC50 = 43.7 nM) compared to CTR2 and RAMP2 complexes (IC50 = 141.3 nM) in amylin radioligand displacement assays. α-CGRP induces cAMP-activated currents in Xenopus oocytes with endogenous Cgrp receptors that overexpress RAMP1 (EC50 = 9 nM). It also induces cAMP accumulation in COS-7 cells transfected with both CTR2 and RAMP1 (EC50 = 8.32 nM).
WARNING This product is not for human or veterinary use.
Technical Information
- α-Calcitonin Gene-Related Peptide (human)
- Calcitonin Gene Related Peptide-1 (human)
- CGRP-1 (human)
- Water: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-13977-1 |
---|---|
Supplier Part Number | 13977-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13977m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 619294-64-3 |