Cayman Adropin Monoclonal Antibody (Clone Cc1133f5); Size- 200 Mi

Adropin is a 76 amino acid secreted peptide expressed in the brain, liver, and plasma and is encoded by the energy homeostasis associated gene.¹ It is highly conserved in mammals, and is involved in glucose homeostasis and lipid metabolism.¹ Plasma levels of adropin decrease with age and have been associated with metabolic disorders such as dyslipidemia and insulin resistance.² Adropin is involved in post-transcriptional activation of eNOS, the up-regulation of VEGFR2, and activation of the ERK1/2 pathway.³ Adropin’s involvement in endothelial cells results in increased proliferation and migration, and decreased permeability and apoptosis.³ Western blot detects adropin at 14-17 kDa in an over-expression cell lysate, and at 25 kDa for SUMO-tagged adropin recombinant protein.

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