Cayman Fen1 (Human Recombinant); Purity- Greater Than Or Equal To

Flap endonuclease 1 (FEN1), a RAD2 Class II nuclease, plays a crucial role in DNA repair, replication, and genomic stability. FEN1 removes the 5-unannealed flap during Okazaki fragment processing in lagging strand DNA synthesis. Removal of the DNA flap is also critical in long-patch base excision repair and regulation of recombination. In yeast, FEN1 mutants display sensitivity to UV irradiation, deficient chromosome segregation, and cell cycle arrest in S phase. Furthermore, haploinsufficiency of FEN1 in mice leads to rapid tumor progression. FEN1 is overexpressed in many forms of cancer, including lung, gastric, prostate, pancreatic, brain, and breast.

WARNING This product is not for human or veterinary use.