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Cayman Pu 02; Purity- Greater Than Or Equal To 98%; Size- 10 Mg;
Cayman Pu 02; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$158.00
Your Price
$158.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-14312-10 |
| MFG.PART: | 14312-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
JNJ-17203212 is a transient receptor potential vanilloid 1 (TRPV1) antagonist (Ki = 72 nM for the recombinant guinea pig channel). It inhibits guinea pig TRPV1 channel activation induced by capsaicin (Item Nos. | ) or pH decrease (IC50s = 58 and 470 nM, respectively). JNJ-17203212 (20 mg/kg) reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs. It reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain when administered at a dose of 30 mg/kg. JNJ-17203212 decreases capsaicin-induced production of calcitonin gene-related peptide (CGRP) in a dose-dependent manner and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[3-
CAS Number
821768-06-3
Molecular Formula
C17H15F6N5O
Formula Weight
419.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
λmax
249 nm
SMILES
FC(F)(F)C1=CC=C(NC(N2CCN(C3=NC=CC=C3C(F)(F)F)CC2)=O)N=C1
InChi Code
InChI=1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
InChi Key
JFRYYGVYCWYIDQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-14312-10 |
|---|---|
| Supplier Part Number | 14312-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/14312m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 313984-77-9 |