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Cayman Jwh 081 N-(4-Hydroxypentyl) Metabolite; Purity- Greater Th
NETA PART: | CAYM-14348-1 |
MFG.PART: | 14348-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan (Item No. ) by GC- or LC-MS. Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM). It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II. Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet. It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin (STZ; Item No. ). Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
- Methanol: Heated
Shipping & Storage Information
SKU | CAYM-14348-1 |
---|---|
Supplier Part Number | 14348-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/14348m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 2748622-62-8 |