Cayman Ay 9944; Purity- Greater Than Or Equal To 98%; Size- 25 Mg

AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ⁷-reductase (DHCR7) enzyme (IC₅₀ = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Item No. 14612) to cholesterol.^1,2 Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused.³ AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models.^2,4 However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.⁵

WARNING This product is not for human or veterinary use.