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Cayman Bace1 (Human, Recombinant); 100 Μg; ≥85% Estimated By Sds-Page
![](https://netam2po.netascientific.info/media/skin/seal2.png)
![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-14645-100 |
MFG.PART: | 14645-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
β-Secretase 1 (BACE1) is an aspartic protease and member of the peptidase A1 protease family.1 BACE1 is transcribed as a preprotein composed of an N-terminal signal peptide, a pro-peptide, a catalytic domain, a transmembrane domain, and a cytosolic domain. The N-terminal signal peptide traffics the BACE1 preprotein to the endoplasmic reticulum where furin-mediated cleavage of the propeptide produces mature BACE1. The transmembrane domain of mature BACE1 drives localization to the Golgi where BACE1 is post-translationally activated and functions at endosomal or Golgi membranes.1,2 BACE1 is expressed primarily in the brain and at lower levels in pancreatic β-cells, adipocytes, hepatocytes, and vascular cells. BACE1 cleaves amyloid precursor protein (APP) to initiate the generation of amyloid-β (Aβ), and BACE1 knockout rescues memory deficits and cholinergic dysfunction in transgenic mouse models of Alzheimers disease.3,4 Additional BACE1 substrates include seizure-related 6 (SEZ6) and seizure-related 6-like (SEZ6L), and BACE1-mediated cleavage of Sez6 and Sez6L is increased in the brain in a mouse model of Niemann-Pick type C disease.5 Caymans BACE1 (human, recombinant) protein can be used for enzyme activity assays.
WARNING This product is not for human or veterinary use.
Technical Information
- β-site Amyloid Precursor Protein Cleaving Enzyme 1
- ASP-2
- BACE
- Memapsin 2
- Membrane-bound Aspartic Protease
- β-secretase 1
Shipping & Storage Information
SKU | CAYM-14645-100 |
---|---|
Supplier Part Number | 14645-100 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
ProductLine | CAYM |
Qty | 100 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |