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Cayman Fsllry-Amide; Purity- Greater Than Or Equal To 95%; Size-
Cayman Fsllry-Amide; Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$241.00
Your Price
$241.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-14709-5 |
MFG.PART: | 14709-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases. It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems. CC-223 inhibits growth and induces apoptosis in hematologic and solid tumor cell lines in vitro, and it exhibits dose-dependent tumor growth inhibition in multiple solid tumor xenografts in vivo.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3,4-dihydro-7 -[6-(1- hydroxy-1- methylethyl)- 3-pyridinyl]- 1-(trans-4- methoxycyclo hexyl)- pyrazino[2,3- b]pyrazin-2 (1H)-one
CAS Number
1228013-30-6
Molecular Formula
C21H27N5O3
Formula Weight
397.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 20 mg/mL
λmax
219, 236, 313, 355 nm
SMILES
CO[C@@H]1CC[C@@H](N2C(CN=C3C2=NC(C4=CN=C(C(O)(C)C)C=C4)=CN3)=O)CC1
InChi Code
InChI=1S/C21H27N5O3/c1-21(2,28)17-9-4-13(10-22-17)16-11-23-19-20(25-16)26(18(27)12-24-19)14-5-7-15(29-3)8-6-14/h4,9-11,14-15,28H,5-8,12H2,1-3H3,(H,23,24)/t14-,15-
InChi Key
UFKLYTOEMRFKAD-SHTZXODSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-14709-5 |
---|---|
Supplier Part Number | 14709-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/14709m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 245329-02-6 |