Cayman Alk5 Inhibitor Ii; Purity- Greater Than Or Equal To 98%; S

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC₅₀s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively).¹ This inhibitor demonstrated less potent activity (IC₅₀s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3.¹ At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.²

WARNING This product is not for human or veterinary use.