Cayman 25i-Nboh (Hydrochloride); Purity- Greater Than Or Equal To

Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8. S1P₄ couples to Gα_i, Gα_o, and Gα_12/13 proteins leading to the stimulation of MAPK/ERK signaling pathways, as well as to PLC and Rho-Cdc42 activation, and is thought to contribute to immune responses. CYM 50308 is a novel agonist of S1P₄ (EC₅₀ = 56 nM) that displays 37-fold selectivity against S1P₅ (EC₅₀ = 2.1 μM) and no appreciable activity over the S1P_1-3 subtypes at concentrations up to 25 μM.

WARNING This product is not for human or veterinary use.