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Cayman Hpob; Purity- Greater Than Or Equal To 95%; Size- 10 Mg
![](https://netam2po.netascientific.info/media/skin/seal2.png)
![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-15066-10 |
MFG.PART: | 15066-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).1 It is at least 30-fold less effective against other HDACs.1 Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.1 HPOB reduces the growth, but not the viability, of normal and transformed cells.1 It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.1 HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft.1
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 10 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 15 mg/ml
Shipping & Storage Information
SKU | CAYM-15066-10 |
---|---|
Supplier Part Number | 15066-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/15066m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1429651-50-2 |