Cayman 2,3-Dinor-6-Keto Prostaglandin F1 Alpha (Sodium Salt); Pur

7-hydroxy DPAT is a dopamine D₃ receptor agonist. It selectively binds to the dopamine D₃ over the D₂, D₁, and D₄ receptors (K_is = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays). 7-hydroxy DPAT increases calcium mobilization in HEK293 cells expressing the D₃ receptor with an EC₅₀ value of 13.5 nM in a FLIPR assay. It decreases the release of striatal dopamine and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. ) in rats when administered intraperitoneally at a dose of 0.25 mg/kg. 7-hydroxy DPAT (2 µg/µl for eight weeks, i.c.v.) reduces the loss of ipsilateral substantia nigra pars compacta (SNC) dopaminergic neurons in a rat model of Parkinsons disease induced by 6-OHDA (Item No. ). It also decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model.

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