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Cayman Ml-161; Purity- Greater Than Or Equal To 95%; Size- 5 Mg;
![](https://netam2po.netascientific.info/media/skin/seal2.png)
![](https://netam2po.netascientific.info/media/skin/seal.png)
NETA PART: | CAYM-15179-5 |
MFG.PART: | 15179-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
The E3 ubiquitin ligase known as murine double minute 2 (MDM2; HDM2 in humans) binds to and then ubiquitinates several proteins, most notably the tumor suppressor p53., JNJ-26854165 is an antagonist of MDM2 that suppresses the growth of cancer cell lines expressing wild-type p53 (IC50 values range from 240-440 nM). It induces p53-mediated transcription culminating in apoptotic death of acute leukemia cells. JNJ-26854165 is orally bioavailable and has anti-proliferative as well as apoptotic actions in various tumor models. As MDM2 interacts with and modulates several targets in addition to p53, JNJ-26854165 affects multiple signaling pathways.,,
WARNING This product is not for human or veterinary use.
Technical Information
- Serdemetan
- DMF: 25 mg/ml
- DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-15179-5 |
---|---|
Supplier Part Number | 15179-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/15179m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 423735-93-7 |