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Cayman Mln4924; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-15217-5 |
MFG.PART: | 15217-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Cytarabine (ara-C) is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively. It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM. ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model. It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg. Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.
WARNING This product is not for human or veterinary use.
Technical Information
- 1-
β- D- Arabinofuranosylcytosine - NSC 63878
- NSC 287459
- U-
19920A
- DMF: 0.1 mg/ml
- DMSO: 0.2 mg/ml
- PBS (pH 7.2): 2 mg/ml
Shipping & Storage Information
SKU | CAYM-15217-5 |
---|---|
Supplier Part Number | 15217-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/15217m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 905579-51-3 |