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Cayman (-)-Cotinine; Purity- Greater Than Or Equal To 98%; Size-
Cayman (-)-Cotinine; Purity- Greater Than Or Equal To 98%; Size- 100 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$73.00
Your Price
$73.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-15314-100 |
| MFG.PART: | 15314-100 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
(–)-Cotinine is an alkaloid that has been found in tobacco plants and an active metabolite of the neuronal nicotinic acetylcholine receptor (nAChR) agonists (±)-nicotine (Item No. ) and (–)-nicotine (Item Nos. | )., It is formed from nicotine by the cytochrome P450 (CYP) isoforms CYP2A6 or CYP2A13 via a 5-hydroxy nicotine intermediate. (–)-Cotinine (1 and 10 µM) reduces the number of dsDNA breaks induced by the tobacco-specific nitrosamine carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; Item No. ) in a comet assay using HepaRG hepatocellular carcinoma cells. In vivo, (–)-cotinine (0.09 µg/kg) increases nicotine self-administration in rats.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-methyl-5S-
CAS Number
486-56-6
Synonyms
- NIH 10498
Molecular Formula
C10H12N2O
Formula Weight
176.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- PBS (pH 7.2): 10 mg/ml
λmax
262 nm
SMILES
O=C1CC[C@@H](C2=CN=CC=C2)N1C
InChi Code
InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChi Key
UIKROCXWUNQSPJ-VIFPVBQESA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-15314-100 |
|---|---|
| Supplier Part Number | 15314-100 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/15314m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CA |
| ProductLine | CAYM |
| Qty | 100 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 486-56-6 |