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Cayman 1-(1-Naphthyl)Piperazine (Hydrochloride); Purity- Greater
Cayman 1-(1-Naphthyl)Piperazine (Hydrochloride); Purity- Greater Than Or Equal To 98%; Size- 250 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$502.00
Your Price
$502.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-16150-250 |
| MFG.PART: | 16150-250 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
IPA-3 is an allosteric inhibitor of p21-activated kinase 1 (PAK1) activation (IC50 = 2.5 µM) that does not inhibit pre-activated PAK1. It selectively inhibits activation of the group I PAKs, PAK1, PAK2, and PAK3 over the group II PAKs, PAK4, PAK5, and PAK6 at 10 µM. IPA-3 inhibits the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) endoribonuclease nsp15 in a FRET assay (IC50 = 6.8 µM) and inhibits SARS-CoV-2 replication in infected Vero CCL-81 cells (IC50 = 8.5 µM). It inhibits the proliferation of H2M and MHCC97-L metastatic hepatocellular carcinoma (HCC) and non-metastatic HepG2 HCC cells when used at concentrations of 5 and 10 µM. IPA-3 (2 and 4 mg/kg) reduces tumor growth in an MHCC97-L cell mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,1-
CAS Number
42521-82-4
Synonyms
- Inhibitor of PAK1 Activation 3
Molecular Formula
C20H14O2S2
Formula Weight
350.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/ml
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml
- DMSO: 5 mg/ml
λmax
223, 357 nm
SMILES
OC1=C(SSC2=C(O)C=CC3=C2C=CC=C3)C4=CC=CC=C4C=C1
InChi Code
InChI=1S/C20H14O2S2/c21-17-11-9-13-5-1-3-7-15(13)19(17)23-24-20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12,21-22H
InChi Key
RFAXLXKIAKIUDT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16150-250 |
|---|---|
| Supplier Part Number | 16150-250 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/16150m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 250 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 104113-71-5 |