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Cayman At7519 (Hydrochloride); Purity- Greater Than Or Equal To 9
NETA PART: | CAYM-16231-1 |
MFG.PART: | 16231-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models., AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 30 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 5 mg/ml
- PBS (pH 7.2): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-16231-1 |
---|---|
Supplier Part Number | 16231-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/16231m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 902135-91-5 |