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Cayman Abt-199; Purity- Greater Than Or Equal To 98%; Size- 25 Mg
NETA PART: | CAYM-16233-25 |
MFG.PART: | 16233-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Piclidenoson is an adenosine A3 receptor agonist (Ki = 1.7 nM). It is selective for adenosine A3 over A1 and A2 receptors (Kis = 55.3 and 3,099 nM, respectively). In vivo, piclidenoson (100 µg/kg) reduces wall thickening in a rabbit model of ischemia-reperfusion injury induced by coronary artery occlusion, an effect that can be reversed by the adenosine receptor antagonist 8-p-sulfophenyl theophylline. It reduces hepatocellular tumor growth, liver inflammation, and neuropathy in a rat model of bone-residing breast cancer and decreases the number of lung metastases in a model of metastatic murine melanoma. Piclidenoson (1 and 3 mg/kg) also reduces colonic inflammatory cell infiltration and damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. ) and in IL-10-/- mice.
WARNING This product is not for human or veterinary use.
Technical Information
- CF-101
- IB-MECA
- DMF: 2mg/mL
- DMSO: 2mg/mL
- DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
Shipping & Storage Information
SKU | CAYM-16233-25 |
---|---|
Supplier Part Number | 16233-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/16233m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1257044-40-8 |