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Cayman O6-Benzylguanine; Purity- Greater Than Or Equal To 98%; Si
Cayman O6-Benzylguanine; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$56.00
Your Price
$56.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-16332-50 |
| MFG.PART: | 16332-50 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
O6-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6-position of guanine from DNA, restoring DNA integrity in a single step.1 In the process, AGT is alkylated and irreversibly inactivated.1 O6-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM.2,3 O6-Benzylguanine is effective in vivo as well as in vitro.4 Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-(phenylmethoxy)-9H-purin-2-amine
CAS Number
19916-73-5
Synonyms
- NSC 637037
Molecular Formula
C12H11N5O
Formula Weight
241.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 5 mg/ml
λmax
242, 284 nm
SMILES
NC1=NC(OCC2=CC=CC=C2)=C3C(NC=N3)=N1
InChi Code
InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
InChi Key
KRWMERLEINMZFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16332-50 |
|---|---|
| Supplier Part Number | 16332-50 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/16332m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CN |
| ProductLine | CAYM |
| Qty | 50 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 19916-73-5 |