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Cayman Gallein, 50mg
Cayman Gallein, 50mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$73.00
Your Price
$73.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-16344-50 |
| MFG.PART: | 16344-50 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Tofacitinib is a potent, cell-permeable inhibitor of all JAK isoforms (IC50s = 6.1, 12, and 8 nM for JAK1, JAK2, and JAK3, respectively). It is selective for JAK1-3 over ROCK2 and Lck (IC50s = 3,400 and 3,870 nM, respectively) as well as 28 additional kinases in enzyme assays (IC50s = >10,000 nM). It inhibits IL-2-mediated phosphorylation of JAK3 and STAT5 when used at a concentration of 30 ng/ml. Tofacitinib prevents rejection and prolongs survival in murine and cynomolgus monkey models of heterotopic heart and kidney transplantation, respectively. Formulations containing tofacitinib have been used in the prevention of organ allograft rejection as well as in the treatment of the inflammatory or autoimmune components of a host of diseases, including rheumatoid arthritis and ulcerative colitis.,,,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3R,4R)-4-methyl-3-(methyl-7H-pyrrolo
CAS Number
540737-29-9
Synonyms
- CP 690,550
Molecular Formula
C16H20N6O • C6H8O7
Formula Weight
504.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
216, 287 nm
SMILES
O=C(CC#N)N1CC[C@@H](C)[C@@H](N(C)C2=NC=NC3=C2C=CN3)C1.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChi Code
InChI=1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+;/m1./s1
InChi Key
SYIKUFDOYJFGBQ-YLAFAASESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16344-50 |
|---|---|
| Supplier Part Number | 16344-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/16344m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CA |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 2103-64-2 |