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Cayman Rizatriptan (Benzoate Salt); Purity- Greater Than Or Equal
NETA PART: | CAYM-16475-10 |
MFG.PART: | 16475-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Chk2 inhibitor is an inhibitor of checkpoint kinase 2 (Chk2; IC50 = 13.5 nM). It is selective for Chk2 over Chk1 (IC50 = 220.4 nM). It inhibits Chk2 autophosphorylation at the serine in position 516 in non-cancerous 184B5 cells that contain wild-type p53 and in MDA-MB-231 cells that contain mutated p53 when used at concentrations ranging from 0.1 to 30 µM. Chk2 inhibitor enhances survival of 184B5, but not MDA-MB-231, cells following ionizing radiation and inhibits cell cycle arrest at the G2 stage induced by ionizing radiation in 184B5 cells. It also inhibits the production of IL-2 in Jurkat cells stimulated by phorbol 12-myristate 13-acetate (PMA; Item No. ) and the production of TNF-α in LPS-stimulated THP-1 cells (IC50s = 3.5 and 8.2 µM, respectively). Chk2 inhibitor also inhibits the growth of CEM leukemia T cells (GI50 = 1.73 µM).
WARNING This product is not for human or veterinary use.
Technical Information
- SC-203885
- DMSO: Soluble
Shipping & Storage Information
SKU | CAYM-16475-10 |
---|---|
Supplier Part Number | 16475-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/16475m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 145202-66-0 |