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Cayman Err (Human) Reporter Assay Kit; Size- 3 X 32 Wells
NETA PART: | CAYM-16524-3 |
MFG.PART: | 16524-3 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
These nuclear receptor assay systems utilize proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of Human ERRγ (also known as NR3B3). Reporter Cells also incorporate a responsive luciferase reporter gene. Quantifying expressed luciferase activity at the assay endpoint provides a sensitive surrogate measure of changes in ERRγ activity in treated cells. As is true in vivo, these reporter cells express ERRγ in a constitutive state of high-level activity in the putative absence of bound ligand. Interestingly, the ligand binding domain of ERRγ may be occupied by a ligand that produces further elevation of the receptor’s constitutive activity (an agonist response). Alternatively, ERRγ may have ligand-binding interactions that results in the loss of constitutive active (an inverse-agonist response). Therefore, the principle application of this assay system is in the screening of test samples to quantify the agonist or inverse-agonist activities that they may exert against human ERRγ.ERRγ Reporter Cells are prepared using INDIGO’s proprietary CryoMite™ process. This cryo-preservation method yields high cell viability post-thaw, and provides the convenience of immediately dispensing healthy, division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps, viability determinations, or cell titer adjustments. [INDIGO Catalog Nos. IB08021-32, IB08021, IB08022]
WARNING This product is not for human or veterinary use.
Technical Information
- ERRγ
- NR3B3
Shipping & Storage Information
SKU | CAYM-16524-3 |
---|---|
Supplier Part Number | 16524-3 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/16524m.pdf |
Temperature | -80 |
Refrigerated-Frozen | Frozen |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |