We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman 4-Nitrophenyl-N-Acetyl- Alphad-Galactosaminide; Purity-
Cayman 4-Nitrophenyl-N-Acetyl- Alpha -D-Galactosaminide; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$363.00
Your Price
$363.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-16755-25 |
| MFG.PART: | 16755-25 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively)., It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines. It is efficacious in a mouse model of JAK2V617F-dependent myeloproliferative neoplasms, although kinase domain mutations can confer resistance., CYT387 also blocks paclitaxel-induced JAK2 activation in ovarian cancer cells, preventing the development of a cancer stem cell-like population following chemotherapy.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
1056634-68-4
Synonyms
- Momelotinib
Molecular Formula
C23H22N6O2
Formula Weight
414.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 14 mg/ml
- DMSO: 16 mg/ml
λmax
292 nm
SMILES
O=C(NCC#N)C(C=C1)=CC=C1C2=NC(NC(C=C3)=CC=C3N4CCOCC4)=NC=C2
InChi Code
InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
InChi Key
ZVHNDZWQTBEVRY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16755-25 |
|---|---|
| Supplier Part Number | 16755-25 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/16755m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | CA |
| ProductLine | CAYM |
| Qty | 25 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 23646-68-6 |