We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Pf-543; Purity- Greater Than Or Equal To 98%; Size- 1 Mg;
Cayman Pf-543; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$32.00
Your Price
$32.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-17034-1 |
MFG.PART: | 17034-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
PF-543 is a potent inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 2 nM) that inhibits sphingosine-1-phosphate (S1P) binding to human recombinant SPHK1 (Ki = 3.6 nM). It is selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at a concentration of 10 µM. PF-543 inhibits the formation of S1P in 1483 cells and human whole blood (EC50s = 8.4 and 26.7 nM, respectively). In vivo, PF-543 prevents sickling, hemolysis, and inflammation in a transgenic mouse model of sickle cell disease.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[[4-[[3- methyl-5- [(phenyl sulfonyl) methyl] phenoxy] methyl] phenyl] methyl]-2R- pyrrolidine methanol, monohydro chloride
CAS Number
1706522-79-3
Molecular Formula
C27H31NO4S • HCl
Formula Weight
502.1
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 25 mg/ml
SMILES
O=S(C1=CC=CC=C1)(CC2=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=CC(C)=C2)=O.Cl
InChi Code
InChI=1S/C27H31NO4S.ClH/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3;1H/t25-;/m1./s1
InChi Key
WNKWAZFYPZMDGJ-VQIWEWKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-17034-1 |
---|---|
Supplier Part Number | 17034-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/17034m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1706522-79-3 |