Cayman Cu-Atsm; Purity- Greater Than Or Equal To 95%; Size- 10 Mg

O⁶-Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O⁶-position of guanine from DNA, restoring DNA integrity in a single step. In the process, AGT is alkylated and irreversibly inactivated. O⁶-Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM.^, O⁶-Benzylguanine is effective in vivo as well as in vitro. Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.

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