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Cayman Azd 8186; Purity- Greater Than Or Equal To 98%; Size- 10 M
NETA PART: | CAYM-17384-10 |
MFG.PART: | 17384-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Doxorubicinol is the major metabolite of doxorubicin (Item No. ), an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks., Doxorubicinol is formed by NADPH-dependent reduction of the side chain carbonyl group of doxorubicin in human, rabbit, and canine cardiac tissue., Doxorubicinol inhibits sodium-potassium-dependent ATPase activity (IC50 = 5.40 μg/ml) and ATP-dependent calcium uptake (IC50= 4.5 μg/ml) in canine cardiac muscle and increases resting stress in contracting rabbit cardiac muscle. Clinically observed cardiotoxicities following doxorubicin treatment have been attributed to the formation and cardiac action of doxorubicinol.,,
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: Soluble
- Methanol: Soluble
Shipping & Storage Information
SKU | CAYM-17384-10 |
---|---|
Supplier Part Number | 17384-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/17384m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1627494-13-6 |