Cayman Cpypp; Size- 25 Mg

CPYPP is an inhibitor of the Rac activators dedicator of cytokinesis 2 (DOCK2; IC₅₀ = 22.8 µM for DOCK2 guanine nucleotide exchange factor (GEF) activity), DOCK5, and DOCK180.^1,2 It is selective for these DOCK-A subfamily proteins over the DOCK-D subfamily member DOCK9.¹ CPYPP (100 µM) prevents chemokine-induced Rac activation in T and B cells. It also inhibits chemokine-induced migration of T and B cells. CPYPP (5 mg/animal, i.p.) reduces migration of T cells to peripheral lymph nodes in mice following adoptive transfer of spleen cells from knock-in mice expressing GFP-tagged DOCK2. It also reduces myeloperoxidase (MPO) activity in lung tissue, LPS-induced cytokine release in serum, and the severity of lung injury in a mouse model of endotoxemia-induced acute lung injury when administered at a dose of 250 mg/kg.³

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