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Cayman Vps34-In1; Purity- Greater Than Or Equal To 98%; Size- 25
Cayman Vps34-In1; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$236.00
Your Price
$236.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-17392-25 |
| MFG.PART: | 17392-25 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Vps34-IN1 is a potent inhibitor of the class III phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34; IC50 = 25 nM in vitro).1 It does not significantly inhibit the activity of over 340 additional kinases, including class I and II PI3Ks. Vps34-IN1 dose-dependently inhibits generation of PtdIns-(3)-p, which is essential to the formation and trafficking of endsomes and autophagosomes, without affecting the ability of class I PI3K to regulate Akt. It induces a rapid and pronounced loss of phosphorylation on serum- and glucocorticoid-regulated kinase 3.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-
CAS Number
1383716-33-3
Synonyms
- Vacuolar Protein Sorting 34 Inhibitor 1
- Vps34 Inhibitor 1
Molecular Formula
C21H24ClN7O
Formula Weight
425.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 35 mg/mL
λmax
286 nm
SMILES
OC(C)(C)CNC1=NC(CC2CC2)=C(C3=CC=NC(NC4=CC=NC(Cl)=C4)=N3)C=N1
InChi Code
InChI=1S/C21H24ClN7O/c1-21(2,30)12-26-19-25-11-15(17(29-19)9-13-3-4-13)16-6-8-24-20(28-16)27-14-5-7-23-18(22)10-14/h5-8,10-11,13,30H,3-4,9,12H2,1-2H3,(H,25,26,29)(H,23,24,27,28)
InChi Key
AWNXKZVIZARMME-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17392-25 |
|---|---|
| Supplier Part Number | 17392-25 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/17392m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 25 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1383716-33-3 |