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Cayman 4-P-Pdot; Purity- Greater Than Or Equal To 98%; Size- 10 M
NETA PART: | CAYM-17411-10 |
MFG.PART: | 17411-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide (Item No. ) by GC- or LC-MS. Flutamide is an androgen receptor antagonist (Kis = 1.3 and 7.5 µM for the cytosolic rat ventral prostate and anterior pituitary receptors, respectively) and prodrug form of 2-hydroxy flutamide (Item No. ). Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft model. Formulations containing flutamide have been used in the treatment of prostate cancer.
WARNING This product is not for human or veterinary use.
Technical Information
- Niftolide-d7
- Methanol: soluble
Shipping & Storage Information
SKU | CAYM-17411-10 |
---|---|
Supplier Part Number | 17411-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/17411m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 134865-74-0 |