Cayman Illudin S; Purity- Greater Than Or Equal To 98%; Size- 1 M

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential.^, Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G₁-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC₅₀ = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin (Item No. ), epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.^,,

WARNING This product is not for human or veterinary use.