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Cayman Gsk106 (Hydrochloride); Purity- Greater Than Or Equal To 9
NETA PART: | CAYM-17490-10 |
MFG.PART: | 17490-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Artesunate-d4 is intended for use as an internal standard for the quantification of artesunate (Item No. ) by GC- or LC-MS. Artesunate is a derivative of artemisinin (Item No. ) that is active against P. falciparum in vitro (IC50 = 1.28 nM). It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It inhibits the activity of the P. falciparum EXP1, a glutathione S-transferase (GST) that degrades hematin, with an IC50 value of 2.05 nM. Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis when administered at a dose of 100 mg/kg twice per day. It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin (Item No. ) in rats. Artesunate increases the activity of GST in mice infected with P. berghei compared to uninfected and infected control animals.
WARNING This product is not for human or veterinary use.
Technical Information
- Artesunic Acid-d4
- Chloroform: slightly soluble
- Methanol: slightly soluble
Shipping & Storage Information
SKU | CAYM-17490-10 |
---|---|
Supplier Part Number | 17490-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/17490m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1652591-82-6 |