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Cayman Cp 91,149; Purity- Greater Than Or Equal To 98%; Size- 10
NETA PART: | CAYM-17709-10 |
MFG.PART: | 17709-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
CP 91,149 is an inhibitor of human liver glycogen phosphorylase a (LGPa), muscle glycogen phosphorylase a (MGPa), and MGPb (IC50s = 0.13, 0.2, and 0.3 μM, respectively, in the presence of glucose).,, CP 91,149 is 5- to 10-fold less potent in the absence of glucose. In vitro, it inhibits glucagon-stimulated glycogenolysis in primary human hepatocytes (IC50 = 2.1 μM) and increases glycogen synthesis in rat hepatocytes at a concentration of 2.5 μM in the presence of 5 mM glucose., CP 91,149 inhibits brain GP (IC50 = 0.5 μM) and, at a concentration of 30 μM, inhibits glycogen accumulation and proliferation of A549 non-small cell lung carcinoma (NSCLC) cells that express endogenous brain GP. In vivo, CP 91,149 (25 mg/kg, p.o.) lowers the plasma glucose level in diabetic ob/ob mice within 3 hours of administration without producing hypoglycemia, but has no effect on normoglycemic, non-diabetic mice.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
Shipping & Storage Information
SKU | CAYM-17709-10 |
---|---|
Supplier Part Number | 17709-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/17709m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 186392-40-5 |