Cayman Tc-E 5002; Purity- Greater Than Or Equal To 98%; Size- 10

TC-E 5002 is an inhibitor of the histone lysine demethylase (KDM) subfamily KDM2/7 (IC₅₀s = 6.8, 0.2, and 1.2 µM for KDM2A, KDM7A, and KDM7B, respectively).¹ It is selective for the KDM2/7 subfamily over KDM4A, KDM4C, KDM5A, and KDM6A/UTX (IC₅₀s = >120, 83, 55, and 100 µM, respectively). It inhibits the growth of N2a, KYSE150, and HeLa cells with GI₅₀ values of 86, 16, and 40 µM, respectively, which are in the range where it increases H3K27me2 levels in KYSE150 and HeLa cells. TC-E 5002 decreases gene expression of E2F1, a transcription factor activated by KDM7B that leads to progression of the cell cycle. In addition, TC-E 5002 treatment leads to cell cycle arrest at the G₀/G₁ phase in KYSE150 and HeLa cells.

WARNING This product is not for human or veterinary use.