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Cayman 4e1rcat; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
NETA PART: | CAYM-18399-1 |
MFG.PART: | 18399-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
LAS191859 is a potent antagonist of CRTH2/DP2 with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively. It is selective for CRTH2/DP2 over a panel of 65 enzymes, ion channels, and transporters with <25% inhibition for all targets when tested at a concentration of 10 μM. LAS191859 reduces shape change of eosinophils (IC50s = 2 and 8.2 nM in isolated eosinophils and whole blood, respectively) and eosinophil chemotaxis (IC50 = 1.3 nM) induced by prostaglandin D2 (PGD2; Item No. ) binding to CRTH2/DP2. Oral administration of LAS191859 reduces PGD2-induced systemic eosinophilia in guinea pigs (ID50 = 131 μg/kg).
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- Ethanol: 2.5 mg/ml
Shipping & Storage Information
SKU | CAYM-18399-1 |
---|---|
Supplier Part Number | 18399-1 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/18399m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 328998-25-0 |