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Cayman Lhw090-A7; Purity- Greater Than Or Equal To 98%; Size- 5 M
NETA PART: | CAYM-18410-5 |
MFG.PART: | 18410-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Fluticasone propionate is a synthetic corticosteroid and glucocorticoid receptor agonist. It inhibits AP-1-mediated transcription in a transrepression assay using ChaGo-K-1 cells (IC50 = 0.04 nM). Fluticasone propionate selectively binds to the glucocorticoid receptor (IC50 = 0.0009 µM) over the progesterone, mineralocorticoid, and androgen receptors (IC50s = 0.021, 0.149, and >10 µM, respectively), as well as estrogen receptor α (ERα) and ERβ (IC50s = >10 µM for both). It increases apoptosis of T cells isolated from human peripheral blood in a concentration-dependent manner and induces spontaneous apoptosis of primary human eosinophils (EC50 = 3.7 nM)., Fluticasone propionate completely inhibits congestion in a guinea pig model of allergic rhinitis induced by ovalbumin when administered as a 0.5 mg/ml solution at 20 µl/nostril. It reduces ovalbumin-induced increases in IL-4 in nasal lavage fluid in the same model. Fluticasone propionate also potentiates voltage-dependent potassium channel 1 (Kv1) currents in an inside-out patch-clamp assay (EC50 = 37 nM). Formulations containing fluticasone propionate have been used in the treatment of allergic and non-allergic rhinitis.
WARNING This product is not for human or veterinary use.
Technical Information
- Fluticasone 17-Propionate
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-18410-5 |
---|---|
Supplier Part Number | 18410-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/18410m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |