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Cayman Cgi1746; Purity- Greater Than Or Equal To 98%; Size- 25 Mg
Cayman Cgi1746; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$246.00
Your Price
$246.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-18414-25 |
MFG.PART: | 18414-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
CGI1746 is a potent, selective inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 1.9 nM), a non-receptor tyrosine kinase that is important in B lymphocyte development.1,2 It blocks both auto-and trans-phosphorylation of BTK by occupying an SH3 binding pocket in the un-phosphorylated enzyme. CGI1746 prevents B-cell antigen receptor-mediated B lymphocyte proliferation and suppresses FCγRIII-induced TNFα, IL-1β, and IL-6 production in macrophages.1 It reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[3-[4,5- dihydro-4- methyl-6-[[4- (4-morpholinyl carbonyl)phenyl] amino]-5-oxo- 2-pyrazinyl]- 2-methylphenyl]- 4-(1,1-dimethyl ethyl)-benzamide
CAS Number
910232-84-7
Molecular Formula
C34H37N5O4
Formula Weight
579.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/ml
- DMSO: 25 mg/ml
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
- Ethanol: 0.25 mg/ml
λmax
234, 355 nm
SMILES
O=C(C1=CC=C(NC2=NC(C3=CC=CC(NC(C4=CC=C(C(C)(C)C)C=C4)=O)=C3C)=CN(C)C2=O)C=C1)N5CCOCC5
InChi Code
InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2,3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16,21H,17-20H2,1-5H3,(H,35,36)(H,37,40)
InChi Key
JIFCFQDXHMUPGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-18414-25 |
---|---|
Supplier Part Number | 18414-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/18414m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 910232-84-7 |