Cayman Prostaglandin J2; Purity- Greater Than Or Equal To 95%; Si

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities.^,, It reduces LPS- and IFN-γ-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM. Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC₅₀ values of 22, 18, 13, and 8.3 µM, respectively. Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks. It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.

WARNING This product is not for human or veterinary use.