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Cayman Ory-1001; Purity- Greater Than Or Equal To 98%; Size- 500
NETA PART: | CAYM-19136-500 |
MFG.PART: | 19136-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ORY-1001 is an inhibitor of lysine-specific demethylase 1 (LSD1), an oxidase that demethylates histone 3 at lysine 4 (H3K4) and H3K9 (IC50 = 0.018 µM).1 It is selective for LSD1 over LSD2, monoamine oxidase A (MAO-A), and MAO-B (IC50s = >100 µM) but does inhibit spermine oxidase (IC50 = 7.4 µM). ORY-1001 also inhibits the imidazoline I2 receptor, norepinephrine and dopamine transporters, and L-type voltage-gated calcium channels (IC50s = 0.37, 2.4, 1.7, and 4.9 µM, respectively). It induces accumulation of dimethylated H3K4 (H3K4me2) in THP-1 cells (EC50 = 0.0022 µM) and reduces viability in a panel of primary acute myeloid leukemia (AML) cells when used at a concentration of 100 nM. ORY-1001 (0.0125 mg/kg) increases survival in a patient-derived xenograft (PDX) mouse model of T cell acute lymphoblastic leukemia (T-ALL). Formulations containing ORY-1001 have been used in the treatment of AML.
WARNING This product is not for human or veterinary use.
Technical Information
- Iadademstat
- RG-6016
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
SKU | CAYM-19136-500 |
---|---|
Supplier Part Number | 19136-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19136m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1431326-61-2 |