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Cayman Umi-77; Purity- Greater Than Or Equal To 98%; Size- 5 Mg;
NETA PART: | CAYM-19148-5 |
MFG.PART: | 19148-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
AZD 3839 is an inhibitor of beta-secretase 1 (BACE1)., It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes). It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 μM). AZD 3839 decreases amyloid-β (Aβ) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively). It dose- and time-dependently decreases Aβ levels in the plasma and brain of mice and guinea pigs. AZD 3839 also decreases Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 μmol/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 2 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-19148-5 |
---|---|
Supplier Part Number | 19148-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/19148m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 518303-20-3 |