Cayman Hsp-990; Purity- Greater Than Or Equal To 98%; Size- 10 Mg

PF-04859989 is an inhibitor of kynurenine aminotransferase II (KAT II; IC₅₀s = 0.032 and 0.263 µM for human and rat recombinant enzymes, respectively). It is selective for KAT II over KAT I, -III, and -IV (IC₅₀s = 21.6, 107, and >50 µM, respectively). In vivo, PF-04859989 (10 mg/kg, s.c.) reduces basal striatum, prefrontal cortex, and hippocampus kynurenic acid levels in rats. It prevents ketamine- or amphetamine-induced disruption of auditory gating in rats, as well as prevents ketamine-induced deficits in spatial memory in non-human primates. PF-04859989 also inhibits glutamate oxaloacetate transaminase 1 (GOT1; IC₅₀ = 8 µM) and reduces the viability of PaTu 8988t and PaTu 8902 pancreatic cancer cells in a concentration-dependent manner.

WARNING This product is not for human or veterinary use.