Cayman Vas2870; Purity- Greater Than Or Equal To 98%; Size- 10 Mg

Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product PGH₂ (Item No. ) into the biologically active PGE₂ (Item No. ). Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1β, and TNF-α. AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE₂ but not PGF_2α (Item No. ) in A549 cells stimulated with IL-1β (IC₅₀s = 2.9 and >100 µM, respectively). It reduces inflammatory pain (acetic acid-induced writhing) in mice by 74% when given intraperitoneally at 10 mg/kg. AF3485 is absorbed through enterocytes, is metabolically stable in human and rat microsome preparations, and is bioavailable in vivo.

WARNING This product is not for human or veterinary use.