Cayman 12-Doxyl Stearic Acid; Purity- Greater Than Or Equal To 95

Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. Three primary types of PLA₂ exist: secretory (sPLA₂), calcium-dependent cytosolic (cPLA₂), and calcium-independent cytosolic (iPLA₂). Of these three enzymes, cPLA₂ is the rate-limiting stimulus for release of arachidonic acid whereas sPLA₂ amplifies the action of cPLA₂ and regulates phagocytosis and foam cell formation. CAY10590, a simple amide based on (R)-γ-norleucine, is a potent and selective inhibitor of sPLA₂. It exhibits 95% inhibition (X_I(50) = 0.003) of sPLA₂ at 0.091 mole fraction without affecting the activities of cPLA₂ or iPLA₂.

WARNING This product is not for human or veterinary use.